On 8 June 2026, the CHANGER Project successfully delivered its second online training session as part of the Intensive Course for the Framework Programme ethics appraisal scheme. The session, titled Gene Editing in Research, brought together participants from across the research ethics community to explore recent developments in gene therapy and the challenges these innovations pose for research ethics review.

The interactive training provided participants with a comprehensive overview of gene editing technologies, including the distinction between germline and somatic gene editing, and examined the current legal and regulatory landscape, with a particular focus on the European context. Discussions also addressed key ethical considerations surrounding gene therapy, including questions of equity and fairness, the assessment of risks and benefits, and the complexities of obtaining meaningful informed consent in rapidly evolving areas of biomedical research.

An important part of the session was dedicated to understanding the patient perspective, highlighting the experiences, expectations and concerns of individuals and communities affected by gene therapy developments.

To encourage practical application of the concepts discussed, the training concluded with a case-study exercise. Participants worked in breakout groups to analyse a research protocol involving gene therapy, identify potential ethical issues, and reflect on the role of research ethics committees in evaluating such proposals. The exercise stimulated lively discussion and provided valuable insights into the challenges of reviewing cutting-edge research involving gene editing technologies.

The recording of the training session is now available online, together with the presentations delivered by the speakers:

• Watch the training video: https://youtu.be/n5Tnfodtfk4
• Download the presentations: Pascal Borry_gene editing general introduction, Margaux Reckelbus_Gene therapy legal landscape, Phaedra Loquet_gene therapy patients’ perspectives and case study

The session forms part of CHANGER’s ongoing efforts to strengthen ethics review capacity and support research ethics committees in addressing emerging ethical issues arising from scientific and technological innovation.

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